Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

In patients with HBV and HCV coinfection, HBV reactivation leading to severe hepatitis has been reported with the use of direct-acting antivirals (DAAs) to treat HCV infection. Here we studied the molecular mechanisms behind this viral interaction. In coinfected cell culture and humanized mice, HBV...

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Publicado en:J Clin Invest
Main Authors: Cheng, Xiaoming, Uchida, Takuro, Xia, Yuchen, Umarova, Regina, Liu, Chun-Jen, Chen, Pei-Jer, Gaggar, Anuj, Suri, Vithika, Mücke, Marcus M., Vermehren, Johannes, Zeuzem, Stefan, Teraoka, Yuji, Osawa, Mitsutaka, Aikata, Hiroshi, Tsuji, Keiji, Mori, Nami, Hige, Shuhei, Karino, Yoshiyasu, Imamura, Michio, Chayama, Kazuaki, Liang, T. Jake
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259999/
https://ncbi.nlm.nih.gov/pubmed/32163375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135616
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