Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

[Image: see text] Recently, we reported that chlorcyclizine (CCZ, Rac-2), an over-the-counter antihistamine piperazine drug, possesses in vitro and in vivo activity against hepatitis C virus. Here, we describe structure–activity relationship (SAR) efforts that resulted in the optimization of novel c...

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Vydáno v:J Med Chem
Hlavní autoři: He, Shanshan, Xiao, Jingbo, Dulcey, Andrés E., Lin, Billy, Rolt, Adam, Hu, Zongyi, Hu, Xin, Wang, Amy Q., Xu, Xin, Southall, Noel, Ferrer, Marc, Zheng, Wei, Liang, T. Jake, Marugan, Juan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753534/
https://ncbi.nlm.nih.gov/pubmed/26599718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00752
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