Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1

Chlorcyclizine (CCZ) is a potent HCV entry inhibitor but its molecular mechanism is unknown. Here we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated substitutions of HCV in vitro revealed six missense mutatio...

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Publicado no:Cell Chem Biol
Main Authors: Hu, Zongyi, Rolt, Adam, Hu, Xin, Ma, Christopher D., Le, Derek J., Park, Seung Bum, Houghton, Michael, Southall, Noel, Anderson, D. Eric, Talley, Daniel C., Lloyd, John R., Marugan, Juan C., Liang, T. Jake
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368827/
https://ncbi.nlm.nih.gov/pubmed/32386595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.04.006
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