Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Fluoxazolevir is an aryloxazole-based entry inhibitor of hepatitis C virus (HCV). We show that fluoxazolevir inhibits fusion of HCV with hepatic cells by binding HCV envelope protein 1 (E1) to prevent fusion. 9 of 10 fluoxazolevir-resistance-associated substitutions are in the E1 protein and 4 are i...

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Veröffentlicht in:Nat Microbiol
Hauptverfasser: Ma, Christopher D., Imamura, Michio, Talley, Daniel C., Rolt, Adam, Xu, Xin, Wang, Amy Q., Le, Derek, Uchida, Takuro, Osawa, Mitsutaka, Teraoka, Yuji, Li, Kelin, Hu, Xin, Park, Seung Bum, Chalasani, Nishanth, Irvin, Parker H., Dulcey, Andres E., Southall, Noel, Marugan, Juan J., Hu, Zongyi, Chayama, Kazuaki, Frankowski, Kevin J., Liang, T. Jake
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677215/
https://ncbi.nlm.nih.gov/pubmed/32868923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0781-2
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