Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1

Chlorcyclizine (CCZ) is a potent HCV entry inhibitor but its molecular mechanism is unknown. Here we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated substitutions of HCV in vitro revealed six missense mutatio...

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發表在:Cell Chem Biol
Main Authors: Hu, Zongyi, Rolt, Adam, Hu, Xin, Ma, Christopher D., Le, Derek J., Park, Seung Bum, Houghton, Michael, Southall, Noel, Anderson, D. Eric, Talley, Daniel C., Lloyd, John R., Marugan, Juan C., Liang, T. Jake
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368827/
https://ncbi.nlm.nih.gov/pubmed/32386595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.04.006
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