Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1

Chlorcyclizine (CCZ) is a potent HCV entry inhibitor but its molecular mechanism is unknown. Here we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated substitutions of HCV in vitro revealed six missense mutatio...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Chem Biol
Autors principals: Hu, Zongyi, Rolt, Adam, Hu, Xin, Ma, Christopher D., Le, Derek J., Park, Seung Bum, Houghton, Michael, Southall, Noel, Anderson, D. Eric, Talley, Daniel C., Lloyd, John R., Marugan, Juan C., Liang, T. Jake
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368827/
https://ncbi.nlm.nih.gov/pubmed/32386595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.04.006
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars