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High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

Using a high-throughput, cell-based HCV luciferase reporter assay to screen a diverse small-molecule compound collection (~300 000 compounds), we identified a benzofuran compound class of HCV inhibitors. The optimization of the benzofuran scaffold led to the identification of several exemplars with...

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הוצא לאור ב:	ACS Comb Sci
Main Authors:	He, Shanshan, Jain, Prashi, Lin, Billy, Ferrer, Marc, Hu, Zongyi, Southall, Noel, Hu, Xin, Zheng, Wei, Neuenswander, Benjamin, Cho, Chul-Hee, Chen, Yu, Worlikar, Shilpa A., Aubé, Jeffrey, Larock, Richard C., Schoenen, Frank J., Marugan, Juan J., Liang, T. Jake, Frankowski, Kevin J.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2015
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6015500/ https://ncbi.nlm.nih.gov/pubmed/26332742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.5b00101
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High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

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