A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐DEL library, constructed in single‐stranded DNA format, allows de...

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Bibliografiske detaljer
Udgivet i:Adv Sci (Weinh)
Main Authors: Bassi, Gabriele, Favalli, Nicholas, Vuk, Miriam, Catalano, Marco, Martinelli, Adriano, Trenner, Anika, Porro, Antonio, Yang, Su, Tham, Chuin Lean, Moroglu, Mustafa, Yue, Wyatt W., Conway, Stuart J., Vogt, Peter K., Sartori, Alessandro A., Scheuermann, Jörg, Neri, Dario
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675038/
https://ncbi.nlm.nih.gov/pubmed/33240760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202001970
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