A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐DEL library, constructed in single‐stranded DNA format, allows de...

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Библиографические подробности
Опубликовано в: :Adv Sci (Weinh)
Главные авторы: Bassi, Gabriele, Favalli, Nicholas, Vuk, Miriam, Catalano, Marco, Martinelli, Adriano, Trenner, Anika, Porro, Antonio, Yang, Su, Tham, Chuin Lean, Moroglu, Mustafa, Yue, Wyatt W., Conway, Stuart J., Vogt, Peter K., Sartori, Alessandro A., Scheuermann, Jörg, Neri, Dario
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
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Full Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675038/
https://ncbi.nlm.nih.gov/pubmed/33240760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202001970
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