Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

BACKGROUND: Frequency of clinically relevant mutations in solid tumors by targeted and whole-exome sequencing is ∼30%. Transcriptome analysis complements detection of actionable gene fusions in advanced cancer patients. Goal of this study was to determine the added value of anchored multiplex PCR (A...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Transl Oncol
Główni autorzy: Beg, Shaham, Bareja, Rohan, Ohara, Kentaro, Eng, Kenneth Wha, Wilkes, David C., Pisapia, David J., Zoughbi, Wael Al, Kudman, Sarah, Zhang, Wei, Rao, Rema, Manohar, Jyothi, Kane, Troy, Sigouros, Michael, Xiang, Jenny Zhaoying, Khani, Francesca, Robinson, Brian D., Faltas, Bishoy M., Sternberg, Cora N., Sboner, Andrea, Beltran, Himisha, Elemento, Olivier, Mosquera, Juan Miguel
Format: Artigo
Język:Inglês
Wydane: Neoplasia Press 2020
Hasła przedmiotowe:
Original article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674614/
https://ncbi.nlm.nih.gov/pubmed/33190043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100944
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