Cancer-Specific Thresholds Adjust for Whole Exome Sequencing–Based Tumor Mutational Burden Distribution

PURPOSE: To understand the clinical context of tumor mutational burden (TMB) when comparing a pan-cancer threshold and a cancer-specific threshold. MATERIALS AND METHODS: Using whole exome sequencing data from primary tumors in The Cancer Genome Atlas (n = 3,534) and advanced and/or metastatic tumor...

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發表在:JCO Precis Oncol
Main Authors: Fernandez, Evan M., Eng, Kenneth, Beg, Shaham, Beltran, Himisha, Faltas, Bishoy M., Mosquera, Juan Miguel, Nanus, David M., Pisapia, David J., Rao, Rema A., Robinson, Brian D., Rubin, Mark A., Elemento, Olivier, Sboner, Andrea, Shah, Manish A., Song, Wei
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2019
主題:
Original Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716608/
https://ncbi.nlm.nih.gov/pubmed/31475242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00400
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