Cancer-Specific Thresholds Adjust for Whole Exome Sequencing–Based Tumor Mutational Burden Distribution

PURPOSE: To understand the clinical context of tumor mutational burden (TMB) when comparing a pan-cancer threshold and a cancer-specific threshold. MATERIALS AND METHODS: Using whole exome sequencing data from primary tumors in The Cancer Genome Atlas (n = 3,534) and advanced and/or metastatic tumor...

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Vydáno v:JCO Precis Oncol
Hlavní autoři: Fernandez, Evan M., Eng, Kenneth, Beg, Shaham, Beltran, Himisha, Faltas, Bishoy M., Mosquera, Juan Miguel, Nanus, David M., Pisapia, David J., Rao, Rema A., Robinson, Brian D., Rubin, Mark A., Elemento, Olivier, Sboner, Andrea, Shah, Manish A., Song, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2019
Témata:
Original Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716608/
https://ncbi.nlm.nih.gov/pubmed/31475242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00400
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