Cancer-Specific Thresholds Adjust for Whole Exome Sequencing–Based Tumor Mutational Burden Distribution

PURPOSE: To understand the clinical context of tumor mutational burden (TMB) when comparing a pan-cancer threshold and a cancer-specific threshold. MATERIALS AND METHODS: Using whole exome sequencing data from primary tumors in The Cancer Genome Atlas (n = 3,534) and advanced and/or metastatic tumor...

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Publicat a:JCO Precis Oncol
Autors principals: Fernandez, Evan M., Eng, Kenneth, Beg, Shaham, Beltran, Himisha, Faltas, Bishoy M., Mosquera, Juan Miguel, Nanus, David M., Pisapia, David J., Rao, Rema A., Robinson, Brian D., Rubin, Mark A., Elemento, Olivier, Sboner, Andrea, Shah, Manish A., Song, Wei
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2019
Matèries:
Original Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716608/
https://ncbi.nlm.nih.gov/pubmed/31475242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00400
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