Cancer-Specific Thresholds Adjust for Whole Exome Sequencing–Based Tumor Mutational Burden Distribution

PURPOSE: To understand the clinical context of tumor mutational burden (TMB) when comparing a pan-cancer threshold and a cancer-specific threshold. MATERIALS AND METHODS: Using whole exome sequencing data from primary tumors in The Cancer Genome Atlas (n = 3,534) and advanced and/or metastatic tumor...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Fernandez, Evan M., Eng, Kenneth, Beg, Shaham, Beltran, Himisha, Faltas, Bishoy M., Mosquera, Juan Miguel, Nanus, David M., Pisapia, David J., Rao, Rema A., Robinson, Brian D., Rubin, Mark A., Elemento, Olivier, Sboner, Andrea, Shah, Manish A., Song, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
Original Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716608/
https://ncbi.nlm.nih.gov/pubmed/31475242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00400
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