Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

BACKGROUND: Frequency of clinically relevant mutations in solid tumors by targeted and whole-exome sequencing is ∼30%. Transcriptome analysis complements detection of actionable gene fusions in advanced cancer patients. Goal of this study was to determine the added value of anchored multiplex PCR (A...

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Publicado en:Transl Oncol
Main Authors: Beg, Shaham, Bareja, Rohan, Ohara, Kentaro, Eng, Kenneth Wha, Wilkes, David C., Pisapia, David J., Zoughbi, Wael Al, Kudman, Sarah, Zhang, Wei, Rao, Rema, Manohar, Jyothi, Kane, Troy, Sigouros, Michael, Xiang, Jenny Zhaoying, Khani, Francesca, Robinson, Brian D., Faltas, Bishoy M., Sternberg, Cora N., Sboner, Andrea, Beltran, Himisha, Elemento, Olivier, Mosquera, Juan Miguel
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2020
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Original article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674614/
https://ncbi.nlm.nih.gov/pubmed/33190043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100944
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