Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance

In this study we investigated the effect of linsitinib on the reversal of multidrug resistance (MDR) mediated by the overexpression of the ATP-binding cassette (ABC) subfamily members ABCB1, ABCG2, ABCC1 and ABCC10. Our results indicate for the first time that linsitinib significantly potentiate the...

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Detalles Bibliográficos
Publicado en:Int J Biochem Cell Biol
Main Authors: Zhang, Hui, Kathawala, Rishil J., Wang, Yi-Jun, Zhang, Yun-Kai, Patel, Atish, Shukla, Suneet, Robey, Robert W., Talele, Tanaji T., Ashby, Charles R., Ambudkar, Suresh V., Bates, Susan E., Fu, Li-Wu, Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670583/
https://ncbi.nlm.nih.gov/pubmed/24726739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2014.03.026
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