First-in-Class Inhibitors of Oncogenic CHD1L With Preclinical Activity Against Colorectal Cancer

Since the discovery of CHD1L in 2008 it has emerged as an oncogene implicated in the pathology and poor prognosis of a variety of cancers, including gastrointestinal cancers. However, a mechanistic understanding of CHD1L as a driver of colorectal cancer (CRC) has been limited. Until now, there have...

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Udgivet i:Mol Cancer Ther
Main Authors: Abbott, Joshua M., Zhou, Qiong, Esquer, Hector, Pike, Laura, Broneske, Travis P., Rinaldetti, Sébastien, Abraham, Adedoyin D., Ramirez, Dominique A., Lunghofer, Paul J., Pitts, Todd M., Regan, Daniel P., Tan, Aik Choon, Gustafson, Daniel L., Messersmith, Wells A., LaBarbera, Daniel V.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665848/
https://ncbi.nlm.nih.gov/pubmed/32499299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0106
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