Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

Combinatorial biosynthesis with fungal polyketide synthases (PKSs) promises to produce unprecedented bioactive “unnatural” natural products (uNPs) for drug discovery. Genome mining of the dothideomycete Rhytidhysteron rufulum uncovered a collaborating highly reducing PKS (hrPKS) – nonreducing PKS (n...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Wang, Chen, Wang, Xiaojing, Zhang, Liwen, Yue, Qun, Liu, Qingpei, Xu, Ya-ming, Gunatilaka, A. A. Leslie, Wei, Xiaoyi, Xu, Yuquan, Molnár, István
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659983/
https://ncbi.nlm.nih.gov/pubmed/32833442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c07050
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