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Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases
Combinatorial biosynthesis with fungal polyketide synthases (PKSs) promises to produce unprecedented bioactive “unnatural” natural products (uNPs) for drug discovery. Genome mining of the dothideomycete Rhytidhysteron rufulum uncovered a collaborating highly reducing PKS (hrPKS) – nonreducing PKS (n...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7659983/ https://ncbi.nlm.nih.gov/pubmed/32833442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c07050 |
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