Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A s...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Chao, Min-Wu, Lin, Tony Eight, HuangFu, Wei-Chun, Chang, Chao-Di, Tu, Huang-Ju, Chen, Liang-Chieh, Yen, Shih-Chung, Sung, Tzu-Ying, Huang, Wei-Jan, Yang, Chia-Ron, Pan, Shiow-Lin, Hsu, Kai-Cheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655034/
https://ncbi.nlm.nih.gov/pubmed/33167727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1843452
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