Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A s...

詳細記述

保存先:
書誌詳細
出版年:J Enzyme Inhib Med Chem
主要な著者: Chao, Min-Wu, Lin, Tony Eight, HuangFu, Wei-Chun, Chang, Chao-Di, Tu, Huang-Ju, Chen, Liang-Chieh, Yen, Shih-Chung, Sung, Tzu-Ying, Huang, Wei-Jan, Yang, Chia-Ron, Pan, Shiow-Lin, Hsu, Kai-Cheng
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2020
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655034/
https://ncbi.nlm.nih.gov/pubmed/33167727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1843452
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