Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A s...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Chao, Min-Wu, Lin, Tony Eight, HuangFu, Wei-Chun, Chang, Chao-Di, Tu, Huang-Ju, Chen, Liang-Chieh, Yen, Shih-Chung, Sung, Tzu-Ying, Huang, Wei-Jan, Yang, Chia-Ron, Pan, Shiow-Lin, Hsu, Kai-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655034/
https://ncbi.nlm.nih.gov/pubmed/33167727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1843452
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