Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. Although the development of DYRK1A inhibitors has significantly advanced...

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Główni autorzy:	Huang-Ju Tu, Min-Wu Chao, Cheng-Chung Lee, Chao-Shiang Peng, Yi-Wen Wu, Tony Eight Lin, Yu-Wei Chang, Shih-Chung Yen, Kai-Cheng Hsu, Shiow-Lin Pan, Wei-Chun HuangFu
Format:	Artigo
Język:	Inglês
Wydane:	Taylor & Francis Group 2024-12-01
Seria:	Journal of Enzyme Inhibition and Medicinal Chemistry
Hasła przedmiotowe:	DYRK1A structure-based virtual screening Tau Aβ
Dostęp online:	https://www.tandfonline.com/doi/10.1080/14756366.2024.2418470
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