A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is ass...

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Detalles Bibliográficos

Principais autores:	Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P. Hanger
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2019-01-01
Series:	Acta Neuropathologica Communications
Assuntos:	Tau Tauopathy Microtubule binding Akt Glycogen synthase kinase-3 Insulin
Acceso en liña:	http://link.springer.com/article/10.1186/s40478-018-0651-9
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