A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is ass...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P. Hanger
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2019-01-01
Σειρά:	Acta Neuropathologica Communications
Θέματα:	Tau Tauopathy Microtubule binding Akt Glycogen synthase kinase-3 Insulin
Διαθέσιμο Online:	http://link.springer.com/article/10.1186/s40478-018-0651-9
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