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Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia

The inhibition of factor XIa (FXIa) is a trending paradigm for the development of new generations of anticoagulants without a substantial risk of bleeding. In this report, we present the discovery of a benzyl tetra‐phosphonate derivative as a potent and selective inhibitor of human FXIa. Biochemical...

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Vydáno v:ChemistryOpen
Hlavní autoři: Kar, Srabani, Mottamal, Madhusoodanan, Al‐Horani, Rami A.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654249/
https://ncbi.nlm.nih.gov/pubmed/33204588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.202000277
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