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PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-mediated Immunometabolism
Pancreatic cancer is an aggressive malignancy with changes in the tumor microenvironment. Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism. Using mouse models of spontaneous pancreatic cancer, we show that...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Dev Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7654182/ https://ncbi.nlm.nih.gov/pubmed/30100261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.07.012 |
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