Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRAS(G12D) is essential for...

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Pubblicato in:Autophagy
Autori principali: Dai, Enyong, Han, Leng, Liu, Jiao, Xie, Yangchun, Kroemer, Guido, Klionsky, Daniel J., Zeh, Herbert J., Kang, Rui, Wang, Jing, Tang, Daolin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595620/
https://ncbi.nlm.nih.gov/pubmed/31920150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1714209
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