Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRAS(G12D) is essential for...

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Vydáno v:Autophagy
Hlavní autoři: Dai, Enyong, Han, Leng, Liu, Jiao, Xie, Yangchun, Kroemer, Guido, Klionsky, Daniel J., Zeh, Herbert J., Kang, Rui, Wang, Jing, Tang, Daolin
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595620/
https://ncbi.nlm.nih.gov/pubmed/31920150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1714209
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