Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRAS(G12D) is essential for...

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發表在:Autophagy
Main Authors: Dai, Enyong, Han, Leng, Liu, Jiao, Xie, Yangchun, Kroemer, Guido, Klionsky, Daniel J., Zeh, Herbert J., Kang, Rui, Wang, Jing, Tang, Daolin
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2020
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595620/
https://ncbi.nlm.nih.gov/pubmed/31920150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1714209
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