Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRAS(G12D) is essential for...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Dai, Enyong, Han, Leng, Liu, Jiao, Xie, Yangchun, Kroemer, Guido, Klionsky, Daniel J., Zeh, Herbert J., Kang, Rui, Wang, Jing, Tang, Daolin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595620/
https://ncbi.nlm.nih.gov/pubmed/31920150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1714209
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