PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-mediated Immunometabolism

Pancreatic cancer is an aggressive malignancy with changes in the tumor microenvironment. Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism. Using mouse models of spontaneous pancreatic cancer, we show that...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Li, Changfeng, Zhang, Ying, Cheng, Xing, Yuan, Hua, Zhu, Shan, Liu, Jiao, Wen, Qirong, Xie, Yangchun, Liu, Jinbao, Kroemer, Guido, Klionsky, Daniel J., Lotze, Michael T., Zeh, Herbert J., Kang, Rui, Tang, Daolin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654182/
https://ncbi.nlm.nih.gov/pubmed/30100261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.07.012
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