AMPK-mediated BECN1 phosphorylation Promotes Ferroptosis by Directly Blocking System X(c)(−) Activity

Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X(c)(−). However, key regulators of system X(c)(−) activity in ferroptosis remain undefined. Here, we show that BECN1 plays a hitherto unsuspected role in promoti...

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Gepubliceerd in:Curr Biol
Hoofdauteurs: Song, Xinxin, Zhu, Shan, Chen, Pan, Hou, Wen, Wen, Qirong, Liu, Jiao, Xie, Yangchun, Liu, Jinbao, Klionsky, Daniel J., Kroemer, Guido, Lotze, Michael T., Zeh, Herbert J., Kang, Rui, Tang, Daolin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081251/
https://ncbi.nlm.nih.gov/pubmed/30057310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.05.094
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