Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

BACKGROUND & AIMS: Induction of non-apoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC). METHODS: We screened 273 commercially available kinase inhibitors...

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Gepubliceerd in:Gastroenterology
Hoofdauteurs: Xie, Yangchun, Zhu, Shan, Zhong, Meizuo, Yang, Minghua, Sun, Xiaofan, Liu, Jinbao, Kroemer, Guido, Lotze, Michael, Zeh, Herbert J., Kang, Rui, Tang, Daolin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670014/
https://ncbi.nlm.nih.gov/pubmed/28764929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.07.036
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