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AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway

Pancreatic ductal adenocarcinoma (PDA), the fourth leading cause of cancer death in the United States, is a complex disease that arises in the setting of genetic alterations (KRAS, BRCA1, SMAD4, CDKN2A/p16(INK4a) and TP53), epigenetic perturbations (MIR155, acetylation and methylation) and epicellul...

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Autors principals: Kang, Rui, Tang, Daolin, Lotze, Michael T., Zeh, III, Herbert J.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427269/
https://ncbi.nlm.nih.gov/pubmed/22722139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.20258
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