Mitochondrial quality control mediated by PINK1 and PRKN: links to iron metabolism and tumor immunity

Mitochondrial quality control is an essential process required to maintain cellular homeostasis and functions. Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease. Our recent findings indicate that depletion of Pink1 and Prkn promotes pancreatic tumorigenesis in KRAS-driven...

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Vydáno v:Autophagy
Hlavní autoři: Kang, Rui, Xie, Yangchun, Zeh, Herbert J., Klionsky, Daniel J., Tang, Daolin
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Commentary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287677/
https://ncbi.nlm.nih.gov/pubmed/30252570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1526611
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