Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. Specifically, the CGAS (cycl...

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Bibliografske podrobnosti
izdano v:Brain
Main Authors: Borsche, Max, König, Inke R, Delcambre, Sylvie, Petrucci, Simona, Balck, Alexander, Brüggemann, Norbert, Zimprich, Alexander, Wasner, Kobi, Pereira, Sandro L, Avenali, Micol, Deuschle, Christian, Badanjak, Katja, Ghelfi, Jenny, Gasser, Thomas, Kasten, Meike, Rosenstiel, Philip, Lohmann, Katja, Brockmann, Kathrin, Valente, Enza Maria, Youle, Richard J, Grünewald, Anne, Klein, Christine
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586086/
https://ncbi.nlm.nih.gov/pubmed/33029617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa246
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