STEM-23. INHIBITING PROTEIN PHOSPHATASE 2A INCREASES THE ANTITUMOR EFFECT OF PROTEIN ARGININE METHYLTRANSFERASE 5 INHIBITION IN MODELS OF GLIOBLASTOMA

BACKGROUND: Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor treating fields, median survival of Glioblastoma (GBM) patients is less than two years. Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues a...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Kumar Banasavadi Siddegowda, Yeshavanth, Sur, Hannah, Otani, Yoshihiro, Rachaiah, Guruprasad, Namagiri, Sriya, Chowdhury, Ashis, Lewis, Cole, Shimizu, Toshihiko, Gangaplara, Arunakumar, Wang, Xiang, Vézina, Amélie, Maric, Dragan, Jackson, Sadhana, Yan, Yuanqing, Zhengping, Zhuang, Ray-Chaudhury, Abhik, Kumar, Sachin, Chittiboina, Prashant, Heiss, John, Yoo, Ji Young, Kaur, Balveen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Cancer Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.840
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