STEM-23. INHIBITING PROTEIN PHOSPHATASE 2A INCREASES THE ANTITUMOR EFFECT OF PROTEIN ARGININE METHYLTRANSFERASE 5 INHIBITION IN MODELS OF GLIOBLASTOMA

BACKGROUND: Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor treating fields, median survival of Glioblastoma (GBM) patients is less than two years. Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues a...

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Vydáno v:Neuro Oncol
Hlavní autoři: Kumar Banasavadi Siddegowda, Yeshavanth, Sur, Hannah, Otani, Yoshihiro, Rachaiah, Guruprasad, Namagiri, Sriya, Chowdhury, Ashis, Lewis, Cole, Shimizu, Toshihiko, Gangaplara, Arunakumar, Wang, Xiang, Vézina, Amélie, Maric, Dragan, Jackson, Sadhana, Yan, Yuanqing, Zhengping, Zhuang, Ray-Chaudhury, Abhik, Kumar, Sachin, Chittiboina, Prashant, Heiss, John, Yoo, Ji Young, Kaur, Balveen
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Cancer Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.840
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