STEM-23. INHIBITING PROTEIN PHOSPHATASE 2A INCREASES THE ANTITUMOR EFFECT OF PROTEIN ARGININE METHYLTRANSFERASE 5 INHIBITION IN MODELS OF GLIOBLASTOMA

BACKGROUND: Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor treating fields, median survival of Glioblastoma (GBM) patients is less than two years. Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues a...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kumar Banasavadi Siddegowda, Yeshavanth, Sur, Hannah, Otani, Yoshihiro, Rachaiah, Guruprasad, Namagiri, Sriya, Chowdhury, Ashis, Lewis, Cole, Shimizu, Toshihiko, Gangaplara, Arunakumar, Wang, Xiang, Vézina, Amélie, Maric, Dragan, Jackson, Sadhana, Yan, Yuanqing, Zhengping, Zhuang, Ray-Chaudhury, Abhik, Kumar, Sachin, Chittiboina, Prashant, Heiss, John, Yoo, Ji Young, Kaur, Balveen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Cancer Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.840
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