STEM-23. INHIBITING PROTEIN PHOSPHATASE 2A INCREASES THE ANTITUMOR EFFECT OF PROTEIN ARGININE METHYLTRANSFERASE 5 INHIBITION IN MODELS OF GLIOBLASTOMA

BACKGROUND: Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor treating fields, median survival of Glioblastoma (GBM) patients is less than two years. Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues a...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Kumar Banasavadi Siddegowda, Yeshavanth, Sur, Hannah, Otani, Yoshihiro, Rachaiah, Guruprasad, Namagiri, Sriya, Chowdhury, Ashis, Lewis, Cole, Shimizu, Toshihiko, Gangaplara, Arunakumar, Wang, Xiang, Vézina, Amélie, Maric, Dragan, Jackson, Sadhana, Yan, Yuanqing, Zhengping, Zhuang, Ray-Chaudhury, Abhik, Kumar, Sachin, Chittiboina, Prashant, Heiss, John, Yoo, Ji Young, Kaur, Balveen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Cancer Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.840
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