STEM-23. INHIBITING PROTEIN PHOSPHATASE 2A INCREASES THE ANTITUMOR EFFECT OF PROTEIN ARGININE METHYLTRANSFERASE 5 INHIBITION IN MODELS OF GLIOBLASTOMA

BACKGROUND: Despite multi-model therapy of maximal surgical resection, radiation, chemotherapy, and tumor treating fields, median survival of Glioblastoma (GBM) patients is less than two years. Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Kumar Banasavadi Siddegowda, Yeshavanth, Sur, Hannah, Otani, Yoshihiro, Rachaiah, Guruprasad, Namagiri, Sriya, Chowdhury, Ashis, Lewis, Cole, Shimizu, Toshihiko, Gangaplara, Arunakumar, Wang, Xiang, Vézina, Amélie, Maric, Dragan, Jackson, Sadhana, Yan, Yuanqing, Zhengping, Zhuang, Ray-Chaudhury, Abhik, Kumar, Sachin, Chittiboina, Prashant, Heiss, John, Yoo, Ji Young, Kaur, Balveen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Cancer Stem Cells
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651384/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.840
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