CSIG-17. PRMT5 INHIBITION SENSITIZES GLIOBLASTOMA MODELS TO TRAMETINIB TREATMENT

INTRODUCTION: Glioblastoma (GBM) is the most common malignant primary brain tumor. With limited effective therapeutic strategies, prognosis for GBM is very poor. Our previous study shows that the expression of Protein Arginine Methyltransferase 5 (PRMT5) is upregulated in GBM; its inhibition promote...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Otani, Yoshihiro, Namagiri, Sriya, Thammegowda, Shilpa, Sur, Hannah, Chowdhury, Ashis, Lewis, Cole, Shimizu, Toshihiko, Lee, Tae Jin, Maric, Dragan, Yoo, Ji Young, Heiss, John, Kaur, Balveen, Banasavadi-Siddegowda, Yeshavanth Kumar
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Cell Signaling and Signaling Pathways
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650434/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.129
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