Oncolytic HSV therapy increases trametinib access to brain tumors and sensitizes them in vivo

BACKGROUND: Hyperactivation of the RAS-RAF-MEK-ERK signaling pathway is exploited by glioma cells to promote their growth and evade apoptosis. MEK activation in tumor cells can increase replication of ICP34.5-deleted herpes simplex virus type 1 (HSV-1), but paradoxically its activation in tumor-asso...

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Vydáno v:Neuro Oncol
Hlavní autoři: Yoo, Ji Young, Swanner, Jessica, Otani, Yoshihiro, Nair, Mitra, Park, Flora, Banasavadi-Siddegowda, Yeshavanth, Liu, Joseph, Jaime-Ramirez, Alena Cristina, Hong, Bangxing, Geng, Feng, Guo, Deliang, Bystry, Darlene, Phelphs, Mitch, Quadri, Haroon, Lee, Tae Jin, Kaur, Balveen
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571492/
https://ncbi.nlm.nih.gov/pubmed/31063549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz079
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