ET-70 COMBINATION OF oHSV WITH INTEGRIN β1 NEUTRALIZING ANTIBODY (OS2966) AUGMENTS oHSV THERAPY

Oncolytic HSV (oHSV) is a biologic therapy currently being tested in patients. We have previously shown that oHSV-induced Cysteine-rich 61 protein (CCN1) binds with integrin α6β1, activating a type 1 IFN-antiviral defense response. oHSV-induced CCN1 induction also increases macrophage infiltration a...

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Main Authors: Yoo, Ji Young, Banasavadi-Siddegowda, Yeshavanth Yeshavanth, Relation, Theresa, Aghi, Manish, Kaur, Balveen
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Abstracts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218167/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.67
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