EXTH-17. MEK KINASE INHIBITOR, TRAMETINIB, SUPPRESSES MACROPHAGE-SECRETED TNF-α ON ONCOLYTIC HSV-1 THERAPY, ENHANCING VIROTHERAPY

Oncolytic herpes simplex viruse-1 (oHSV) therapy is currently FDA-approved for advanced melanoma and is currently being evaluated in several clinical trials. However, its clinical success has been limited and various combinatorial treatment modalities are being investigated to enhance the efficacy o...

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Publicat a:Neuro Oncol
Autors principals: Yoo, Ji Young, Lee, Tae Jin, Liu, Joseph, Jaime-Ramirez, Alena Cristina, Weiss, Alexander, Russell, Luke, Nallanagulagari, Tejaswini, Zhang, Jianying, Kaur, Balveen
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693209/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.312
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