EXTH-17. MEK KINASE INHIBITOR, TRAMETINIB, SUPPRESSES MACROPHAGE-SECRETED TNF-α ON ONCOLYTIC HSV-1 THERAPY, ENHANCING VIROTHERAPY

Oncolytic herpes simplex viruse-1 (oHSV) therapy is currently FDA-approved for advanced melanoma and is currently being evaluated in several clinical trials. However, its clinical success has been limited and various combinatorial treatment modalities are being investigated to enhance the efficacy o...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Yoo, Ji Young, Lee, Tae Jin, Liu, Joseph, Jaime-Ramirez, Alena Cristina, Weiss, Alexander, Russell, Luke, Nallanagulagari, Tejaswini, Zhang, Jianying, Kaur, Balveen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693209/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.312
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