EXTH-17. MEK KINASE INHIBITOR, TRAMETINIB, SUPPRESSES MACROPHAGE-SECRETED TNF-α ON ONCOLYTIC HSV-1 THERAPY, ENHANCING VIROTHERAPY

Oncolytic herpes simplex viruse-1 (oHSV) therapy is currently FDA-approved for advanced melanoma and is currently being evaluated in several clinical trials. However, its clinical success has been limited and various combinatorial treatment modalities are being investigated to enhance the efficacy o...

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Publicado en:Neuro Oncol
Autores principales: Yoo, Ji Young, Lee, Tae Jin, Liu, Joseph, Jaime-Ramirez, Alena Cristina, Weiss, Alexander, Russell, Luke, Nallanagulagari, Tejaswini, Zhang, Jianying, Kaur, Balveen
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Abstracts
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693209/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.312
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