PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

Engineered oncolytic viruses are used clinically to destroy cancer cells and have the ability to boost anticancer immunity. Phosphatase and tensin homolog deleted on chromosome 10 loss is common across a broad range of malignancies, and is implicated in immune escape. The N-terminally extended isofo...

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Publicat a:Nat Commun
Autors principals: Russell, Luke, Swanner, Jessica, Jaime-Ramirez, Alena Cristina, Wang, Yufeng, Sprague, Alex, Banasavadi-Siddegowda, Yeshavanth, Yoo, Ji Young, Sizemore, Gina M., Kladney, Raleigh, Zhang, Jianying, Lehman, Norman L., Ostrowski, Michael C, Hong, Bangxing, Caligiuri, Michael, Yu, Jianhua, Kaur, Balveen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258708/
https://ncbi.nlm.nih.gov/pubmed/30479334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07344-1
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