EXTH-12. INHIBITION OF CBP/p300 HISTONE ACETYLATION ACTIVITY ENHANCES TEMOZOLOMIDE ACTIVITY IN GLIOBLASTOMA PATIENT DERIVED XENOGRAFTS

There is an unmet need to identify novel targets that can sensitize temozolomide (TMZ) or prevent resistance in GBM. We have demonstrated that retinoblastoma binding protein 4 (RBBP4) interacts with p300 to modulate expression of genes involved in homologous recombination (HR), including RAD51. In v...

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Vydáno v:Neuro Oncol
Hlavní autoři: Kitange, Gaspar J, Burgenske, Danielle M, Bakken, Katrina K, Hu, Zeng, He, Lihong, Carlson, Brett L, Wilson, Jonathan, Bommi-Reddy, Archana, Conery, Andy, Sarkaria, Jann
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Preclinical Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651330/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.366
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