EXTH-12. INHIBITION OF CBP/p300 HISTONE ACETYLATION ACTIVITY ENHANCES TEMOZOLOMIDE ACTIVITY IN GLIOBLASTOMA PATIENT DERIVED XENOGRAFTS

There is an unmet need to identify novel targets that can sensitize temozolomide (TMZ) or prevent resistance in GBM. We have demonstrated that retinoblastoma binding protein 4 (RBBP4) interacts with p300 to modulate expression of genes involved in homologous recombination (HR), including RAD51. In v...

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Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Kitange, Gaspar J, Burgenske, Danielle M, Bakken, Katrina K, Hu, Zeng, He, Lihong, Carlson, Brett L, Wilson, Jonathan, Bommi-Reddy, Archana, Conery, Andy, Sarkaria, Jann
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Preclinical Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651330/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.366
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