EXTH-12. INHIBITION OF CBP/p300 HISTONE ACETYLATION ACTIVITY ENHANCES TEMOZOLOMIDE ACTIVITY IN GLIOBLASTOMA PATIENT DERIVED XENOGRAFTS

There is an unmet need to identify novel targets that can sensitize temozolomide (TMZ) or prevent resistance in GBM. We have demonstrated that retinoblastoma binding protein 4 (RBBP4) interacts with p300 to modulate expression of genes involved in homologous recombination (HR), including RAD51. In v...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kitange, Gaspar J, Burgenske, Danielle M, Bakken, Katrina K, Hu, Zeng, He, Lihong, Carlson, Brett L, Wilson, Jonathan, Bommi-Reddy, Archana, Conery, Andy, Sarkaria, Jann
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Preclinical Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651330/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.366
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