EXTH-01. INHIBITION OF DNA-PKcs BY M3814 POTENTIATES EFFICACY OF IONIZING RADIATION IN PATIENT-DERIVED XENOGRAFTS OF MELANOMA BRAIN METASTASES

Radio-resistance mechanisms limit the benefit of radiation therapy (RT) for melanoma brain metastases. A key pathway for radiation-induced DNA double-strand break repair is non-homologous end joining, which is critically mediated by DNA-dependent protein kinase (DNA-PK(cs)). Here we evaluated radio-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: Ji, Jianxiong, Smith, Emily, Sarkaria, Paige, Mladek, Ann, Talele, Surabhi, Swanson, Katelyn, Mohammad, Afroz S, Zhang, Wenjuan, He, Lihong, Hu, Zeng, Zhao, Yu, Chen, Jiajia, Connors, Margaret A, Porath, Kendra A, Bakken, Katrina K, Dragojevic, Sonja, Carlson, Brett L, Gupta, Shiv K, Burgenske, Danielle M, Kitange, Gaspar J, Elmquist, William F, Sarkaria, Jann
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Preclinical Experimental Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651301/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.355
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak