EXTH-01. INHIBITION OF DNA-PKcs BY M3814 POTENTIATES EFFICACY OF IONIZING RADIATION IN PATIENT-DERIVED XENOGRAFTS OF MELANOMA BRAIN METASTASES

Radio-resistance mechanisms limit the benefit of radiation therapy (RT) for melanoma brain metastases. A key pathway for radiation-induced DNA double-strand break repair is non-homologous end joining, which is critically mediated by DNA-dependent protein kinase (DNA-PK(cs)). Here we evaluated radio-...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Ji, Jianxiong, Smith, Emily, Sarkaria, Paige, Mladek, Ann, Talele, Surabhi, Swanson, Katelyn, Mohammad, Afroz S, Zhang, Wenjuan, He, Lihong, Hu, Zeng, Zhao, Yu, Chen, Jiajia, Connors, Margaret A, Porath, Kendra A, Bakken, Katrina K, Dragojevic, Sonja, Carlson, Brett L, Gupta, Shiv K, Burgenske, Danielle M, Kitange, Gaspar J, Elmquist, William F, Sarkaria, Jann
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Preclinical Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651301/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.355
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